Of cloned pigs and PERV
نویسندگان
چکیده
منابع مشابه
Production and Breeding of Transgenic Cloned Pigs Expressing Human CD73
One of the reasons to causing blood coagulation in the tissue of xenografted organs was known to incompatibility of the blood coagulation and anti-coagulation regulatory system between TG pigs and primates. Thus, overexpression of human CD73 (hCD73) in the pig endothelial cells is considered as a method to reduce coagulopathy after pig-to-non-human-primate xenotransplantation. This study was pe...
متن کاملProduction of Cloned Pigs with Targeted Attenuation of Gene Expression
The objective of this study was to demonstrate that RNA interference (RNAi) and somatic cell nuclear transfer (SCNT) technologies can be used to attenuate the expression of specific genes in tissues of swine, a large animal species. Apolipoprotein E (apoE), a secreted glycoprotein known for its major role in lipid and lipoprotein metabolism and transport, was selected as the target gene for thi...
متن کاملSenescence is accelerated through donor cell specificity in cloned pigs.
Animals cloned by somatic cell nuclear transfer (SCNT) sometimes have abnormalities that result in large offspring syndrome or early death during gestation due to respiratory and metabolic defects. We cloned pigs using two sources of donor cells and observed phenotypic anomalies in three pigs cloned from one type of cell, s-pig fetal fibroblasts. ...
متن کاملDevelopment of sensitive methods for detection of porcine endogenous retrovirus-C (PERV-C) in the genome of pigs.
Porcine endogenous retroviruses (PERV) represent a risk for xenotransplantation using pig cells, tissues or organs. PERV-A and PERV-B are present in the genome of all pigs and both infect human cells in vitro. PERV-C infects only pig cells and it is integrated in the genome of most, but not all pigs. Recombinants between PERV-A and PERV-C were described that infect human cells and replicate at ...
متن کاملChanges in the gut microbiota of cloned and non-cloned control pigs during development of obesity: gut microbiota during development of obesity in cloned pigs - DTU Orbit (18/06/2017)
obesity: gut microbiota during development of obesity in cloned pigs DTU Orbit (18/06/2017) Changes in the gut microbiota of cloned and non-cloned control pigs during development of obesity: gut microbiota during development of obesity in cloned pigs Background Obesity induced by a high-caloric diet has previously been associated with changes in the gut microbiota in mice and in humans. In thi...
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ژورنال
عنوان ژورنال: Genome Biology
سال: 2000
ISSN: 1465-6906
DOI: 10.1186/gb-spotlight-20000818-01